† Equal contributors
1 Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
2 Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy

Results indicate that nutritional modulation of critical proteins involved in brain stress tolerance can be achieved via supplementation with a well characterized strain of Hericium erinaceus biomass. These findings are relevant to those theories connecting faulty protein quality control mechanisms with age-associated neurodegenerative diseases

There is a body of thought that viruses such as the herpes simplex virus (HSV-1) is a contributing factor in the development of Alzheimer´s disease. In addition, Dr LaFerla at the University of California has suggested the activation of Lipoxin A4 (LXA4) could reduce the progress of (or delay the onset of) Alzheimer´s disease. This article provides the rationale for the use of mushroom nutrition (in the form of a combination of Coriolus versicolor and Hericium erinaceus (biomass)), to provide both anti-viral protection and activation of LXA4.